Diabetes mellitus is a chronic, systemic, metabolic disease caused by the long-term combination of genetic factors and environmental factors, characterized by increased plasma glucose levels, mainly due to insufficient insulin secretion or dysfunction in the body (insulin resistance). Diabetes can be categorized into three primary forms – type 1, type 2, and gestational diabetes – each with distinct underlying causes. With the prevalence of diabetes increasing at an alarming rate, there is a critical need for innovative research solutions to better understand and combat this epidemic. The use of mouse models enables the study of diabetes in a way that closely mirrors the disease in humans, helping to explore disease mechanisms, find biomarkers, and evaluate potential treatments.